Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 426 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Milk Thistle Extract(Silybum marianum) (Fruit/Seed)(Standardized to 240 mg Silymarin Flavonoids - equivalent 80%)
300 mg
**
Dandelion Root (Taraxacum officinale)
100 mg
**
Artichoke (Cynara scolymus) (Leaf)
50 mg
**
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Read More
Most Useful Reviews
7.5
Liver recovery observed
1382 people found this helpful
Recently, I discovered that I have liver disease after tests revealed high enzyme levels. In a panic, I researched and learned that the liver has remarkable self-restorative abilities. I started a diet and looked into dietary supplements, purchasing one containing milk thistle and artichoke extract. Although I can't be certain of its specific effects, my tests returned to normal after a month. I recommend looking into these supplements for liver support.
Read More
8.5
Liver support recommended
1114 people found this helpful
Silymarin, derived from milk thistle, has numerous health benefits as a hepatoprotector and antioxidant. It addresses liver dysfunction and promotes overall health. I've recommended silymarin for treating liver disease and advocate its use as a preventive measure. However, there are contraindications, so please consult a doctor before use.
Read More
9
Gallbladder function improved
586 people found this helpful
Excellent silymarin! It supports liver function and has greatly improved my gallbladder health. After finishing a can, the strong bitterness in my mouth vanished. I encourage everyone to consider taking silymarin as a preventive measure for liver disease and overall well-being.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Read More
9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 426 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Liver recovery observed
1382 people found this helpful
Recently, I discovered that I have liver disease after tests revealed high enzyme levels. In a panic, I researched and learned that the liver has remarkable self-restorative abilities. I started a diet and looked into dietary supplements, purchasing one containing milk thistle and artichoke extract. Although I can't be certain of its specific effects, my tests returned to normal after a month. I recommend looking into these supplements for liver support.
Read More
8.5
Liver support recommended
1114 people found this helpful
Silymarin, derived from milk thistle, has numerous health benefits as a hepatoprotector and antioxidant. It addresses liver dysfunction and promotes overall health. I've recommended silymarin for treating liver disease and advocate its use as a preventive measure. However, there are contraindications, so please consult a doctor before use.
Read More
9
Gallbladder function improved
586 people found this helpful
Excellent silymarin! It supports liver function and has greatly improved my gallbladder health. After finishing a can, the strong bitterness in my mouth vanished. I encourage everyone to consider taking silymarin as a preventive measure for liver disease and overall well-being.
Read More
9
Pain relief achieved
361 people found this helpful
I love milk thistle! With 80% silymarin, it works wonderfully. Just a couple of capsules during breakfast alleviated my right hypochondrium pain. It protects liver cells from toxins, and I'm already noticing recovery from fatty liver disease. I recommend this effective and high-quality product!
Read More
9
Effective liver cleansing
350 people found this helpful
This NOW Foods Milk Thistle has been fantastic for my chronic liver issues. Only one capsule is needed, which makes it stand out. It effectively detoxifies the liver, improving my overall health. There’s a noticeable difference even after a week of use. Highly recommend this supplement for liver disease.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. doi:10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. doi:10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. doi:10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. doi:10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. doi:10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. doi:10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. doi:10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. doi:10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. doi:10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. doi:10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. doi:10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. doi:10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. doi:10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. doi:10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
